2.3M
XNAS Volume
High volume+loss today
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Roy D. Baynes | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Mar 2025 | 50,000 | 50,000 | - | - | Director Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 14.40 per share. | 03 Mar 2025 | 5,125 | 34,424 | - | 14.4 | 73,797 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.13 per share. | 03 Mar 2025 | 700 | 33,724 | - | 15.1 | 10,591 | Common Stock |
| Hans van Houte | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 75,000 | 75,000 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 34,300 | 34,300 | - | - | Restricted Stock Units | |
| Arthur T. Sands | Director, President, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 450,000 | 450,000 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 34,300 | 34,300 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 75,000 | 75,000 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 75,000 | 75,000 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2025 | 34,300 | 34,300 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 31 Jan 2025 | 223 | 32,761 | - | 1.9 | 415 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 5,537 | 0 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Jan 2025 | 223 | 53,763 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 20.48 per share. | 31 Jan 2025 | 100 | 32,538 | - | 20.5 | 2,048 | Common Stock |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 19.94 per share. | 31 Jan 2025 | 5,660 | 32,638 | - | 19.9 | 112,886 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 31 Jan 2025 | 5,537 | 38,298 | - | 1.9 | 10,299 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 3,207 | 53,877 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 3,750 | 33,750 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 2,000 | 10,000 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 3,207 | 12,827 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 20.32 per share. | 30 Jan 2025 | 333 | 55,937 | - | 20.3 | 6,768 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 19.81 per share. | 30 Jan 2025 | 3,357 | 56,270 | - | 19.8 | 66,491 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 3,750 | 59,627 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 2,000 | 55,877 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 3,750 | 33,750 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 1,924 | 30,008 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 2,000 | 32,008 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 3,750 | 35,758 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 19.81 per share. | 30 Jan 2025 | 2,929 | 32,829 | - | 19.8 | 58,014 | Common Stock |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 20.33 per share. | 30 Jan 2025 | 291 | 32,538 | - | 20.3 | 5,915 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 1,924 | 7,697 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 2,000 | 10,000 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 2,000 | 38,610 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 19.81 per share. | 30 Jan 2025 | 2,557 | 39,803 | - | 19.8 | 50,646 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 3,750 | 42,360 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 2,886 | 36,610 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 2,000 | 10,000 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 3,750 | 33,750 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2025 | 2,886 | 11,545 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.33 per share. | 30 Jan 2025 | 254 | 39,549 | - | 20.3 | 5,163 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Jan 2025 | 5,760 | 53,986 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 02 Jan 2025 | 5,760 | 33,844 | - | 1.9 | 10,714 | Common Stock |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 19.50 per share. | 02 Jan 2025 | 5,760 | 28,084 | - | 19.5 | 112,295 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Dec 2024 | 5,760 | 59,746 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 21.73 per share. | 02 Dec 2024 | 5,760 | 28,084 | - | 21.7 | 125,155 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 02 Dec 2024 | 5,760 | 33,844 | - | 1.9 | 10,714 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.57 per share. | 04 Nov 2024 | 3,290 | 31,374 | - | 9.6 | 31,485 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2024 | 3,290 | 96,389 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 04 Nov 2024 | 3,290 | 28,084 | - | 25 | 82,250 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 01 Nov 2024 | 5,760 | 33,844 | - | 1.9 | 10,714 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2024 | 5,760 | 65,506 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 24.28 per share. | 01 Nov 2024 | 5,760 | 28,084 | - | 24.3 | 139,867 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 24.28 per share. | 01 Nov 2024 | 3,546 | 33,724 | - | 24.3 | 86,083 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 3,207 | 48,357 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 3,750 | 37,500 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 2,000 | 12,000 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 3,207 | 16,034 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 24.30 per share. | 30 Oct 2024 | 3,437 | 50,670 | - | 24.3 | 83,536 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 3,750 | 54,107 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 2,000 | 50,357 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 1,924 | 26,516 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 3,750 | 37,500 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 2,000 | 12,000 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 1,924 | 9,621 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 24.31 per share. | 30 Oct 2024 | 4,182 | 28,084 | - | 24.3 | 101,644 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 3,750 | 32,266 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 2,000 | 28,516 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 2,886 | 33,888 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 3,750 | 37,500 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 2,000 | 12,000 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 2,886 | 14,431 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 24.30 per share. | 30 Oct 2024 | 2,368 | 37,270 | - | 24.3 | 57,554 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 3,750 | 39,638 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2024 | 2,000 | 35,888 | - | 0 | Common Stock | |
| Anil Kapur | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Oct 2024 | 50,000 | 50,000 | - | - | Director Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 25.00 per share. | 14 Oct 2024 | 3,290 | 24,592 | - | 25 | 82,250 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Oct 2024 | 3,290 | 99,679 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.57 per share. | 14 Oct 2024 | 3,290 | 27,882 | - | 9.6 | 31,485 | Common Stock |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 22.81 per share. | 01 Oct 2024 | 300 | 24,592 | - | 22.8 | 6,843 | Common Stock |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 22.19 per share. | 01 Oct 2024 | 5,460 | 24,892 | - | 22.2 | 121,174 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 01 Oct 2024 | 5,760 | 30,352 | - | 1.9 | 10,714 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2024 | 5,760 | 71,266 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 03 Sep 2024 | 5,760 | 30,352 | - | 1.9 | 10,714 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 3,290 | 102,969 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Sep 2024 | 5,760 | 77,026 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 25.62 per share. | 03 Sep 2024 | 200 | 24,592 | - | 25.6 | 5,124 | Common Stock |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 24.93 per share. | 03 Sep 2024 | 8,850 | 24,792 | - | 24.9 | 220,612 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.57 per share. | 03 Sep 2024 | 3,290 | 33,642 | - | 9.6 | 31,485 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 5,407 | 106,259 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Aug 2024 | 4,463 | 5,537 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 25.01 per share. | 26 Aug 2024 | 9,870 | 24,592 | - | 25.0 | 246,843 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.57 per share. | 26 Aug 2024 | 5,407 | 34,462 | - | 9.6 | 51,745 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 26 Aug 2024 | 4,463 | 29,055 | - | 1.9 | 8,301 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 25.22 per share. | 26 Aug 2024 | 20,000 | 31,002 | - | 25.2 | 504,370 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Aug 2024 | 5,760 | 82,786 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 22.18 per share. | 01 Aug 2024 | 300 | 24,592 | - | 22.2 | 6,655 | Common Stock |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 21.39 per share. | 01 Aug 2024 | 5,460 | 24,892 | - | 21.4 | 116,804 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 01 Aug 2024 | 5,760 | 30,352 | - | 1.9 | 10,714 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 22.22 per share. | 01 Aug 2024 | 100 | 51,002 | - | 22.2 | 2,222 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 21.43 per share. | 01 Aug 2024 | 3,377 | 51,102 | - | 21.4 | 72,354 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 3,750 | 48,558 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 3,207 | 42,808 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 3,750 | 41,250 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 2,000 | 14,000 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 3,207 | 19,241 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 20.67 per share. | 30 Jul 2024 | 3,408 | 45,150 | - | 20.7 | 70,436 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 2,000 | 44,808 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 1,924 | 21,762 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 3,750 | 41,250 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 2,000 | 14,000 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 1,924 | 11,545 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 20.67 per share. | 30 Jul 2024 | 2,920 | 24,592 | - | 20.7 | 60,350 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 3,750 | 27,512 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 2,000 | 23,762 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.67 per share. | 30 Jul 2024 | 2,490 | 54,479 | - | 20.7 | 51,463 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 3,750 | 41,250 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 2,000 | 14,000 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 2,886 | 17,317 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 3,750 | 56,969 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 2,000 | 53,219 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2024 | 2,886 | 51,219 | - | 0 | Common Stock | |
| Lori Anne Kunkel | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 17 Jul 2024 | 54,027 | 0 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2024 | 5,760 | 88,546 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 21.57 per share. | 01 Jul 2024 | 801 | 19,838 | - | 21.6 | 17,277 | Common Stock |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 20.68 per share. | 01 Jul 2024 | 4,959 | 20,639 | - | 20.7 | 102,560 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 01 Jul 2024 | 5,760 | 25,598 | - | 1.9 | 10,714 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 20.01 per share. | 20 Jun 2024 | 20,000 | 48,333 | - | 20.0 | 400,216 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jun 2024 | 1,864 | 94,306 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 17.02 per share. | 13 Jun 2024 | 1,864 | 19,838 | - | 17.0 | 31,721 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 13 Jun 2024 | 1,864 | 21,702 | - | 1.9 | 3,467 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2024 | 1,900 | 96,170 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 12 Jun 2024 | 1,900 | 21,738 | - | 1.9 | 3,534 | Common Stock |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 17.01 per share. | 12 Jun 2024 | 1,900 | 19,838 | - | 17.0 | 32,319 | Common Stock |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 17.00 per share. | 05 Jun 2024 | 400 | 19,838 | - | 17.0 | 6,801 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jun 2024 | 400 | 98,070 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 05 Jun 2024 | 400 | 20,238 | - | 1.9 | 744 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2024 | 1,596 | 98,470 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 17.01 per share. | 03 Jun 2024 | 1,596 | 19,838 | - | 17.0 | 27,153 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 03 Jun 2024 | 1,596 | 21,434 | - | 1.9 | 2,969 | Common Stock |
| Julia P. Gregory | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2024 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| Judith A. Reinsdorf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2024 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| Paul M. Silva | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2024 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| Lori Anne Kunkel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2024 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| David L. Lacey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2024 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| Edward C. Saltzman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2024 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.83 per share. | 02 May 2024 | 3,499 | 68,333 | - | 12.8 | 44,878 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 3,206 | 39,608 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 2,000 | 16,000 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 3,206 | 22,448 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 12.04 per share. | 30 Apr 2024 | 2,007 | 39,601 | - | 12.0 | 24,169 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 2,000 | 41,608 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 1,924 | 19,351 | - | 0 | Common Stock | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 2,000 | 16,000 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 1,924 | 13,469 | - | - | Restricted Stock Units | |
| Christine Ring | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 12.04 per share. | 30 Apr 2024 | 1,513 | 19,838 | - | 12.0 | 18,220 | Common Stock |
| Christine Ring | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 2,000 | 21,351 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 2,886 | 71,219 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 2,000 | 16,000 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 2,886 | 20,203 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.04 per share. | 30 Apr 2024 | 1,387 | 71,832 | - | 12.0 | 16,703 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2024 | 2,000 | 73,219 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.02 per share. | 16 Feb 2024 | 6,812 | 68,333 | - | 10.0 | 68,223 | Common Stock |
| Hansen Gwenn | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 45,000 | 45,000 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 45,000 | 45,000 | - | - | Restricted Stock Units | |
| Ring Christine | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 45,000 | 45,000 | - | - | Restricted Stock Units | |
| van Houte Hans | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Arthur Sands T. | Director, President, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 800,000 | 800,000 | - | - | Employee Stock Option (right to buy) | |
| Ring Christine | Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 7.99 per share. | 30 Jan 2024 | 1,760 | 17,427 | - | 8.0 | 14,063 | Common Stock |
| Ring Christine | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 1,924 | 17,187 | - | 0 | Common Stock | |
| van Houte Hans | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 7.99 per share. | 30 Jan 2024 | 1,671 | 75,145 | - | 8.0 | 13,352 | Common Stock |
| van Houte Hans | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 2,000 | 76,816 | - | 0 | Common Stock | |
| Ring Christine | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 1,924 | 15,393 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 3,207 | 25,654 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 3,207 | 36,736 | - | 0 | Common Stock | |
| Ring Christine | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 2,000 | 18,000 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 2,886 | 23,089 | - | - | Restricted Stock Units | |
| van Houte Hans | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 2,000 | 18,000 | - | - | Restricted Stock Units | |
| Ring Christine | Chief Legal Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 2,000 | 19,187 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 7.99 per share. | 30 Jan 2024 | 2,334 | 36,402 | - | 8.0 | 18,649 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 2,000 | 38,736 | - | 0 | Common Stock | |
| Hansen Gwenn | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 2,000 | 18,000 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2024 | 2,886 | 74,816 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.00 per share. | 20 Dec 2023 | 3,541 | 71,930 | - | 10.0 | 35,421 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 10.00 per share. | 19 Dec 2023 | 10,906 | 75,471 | - | 10.0 | 109,093 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 3,207 | 29,839 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 2,000 | 22,000 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 3,207 | 32,068 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 9.65 per share. | 30 Jul 2023 | 1,884 | 29,955 | - | 9.7 | 18,189 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 2,000 | 31,839 | - | 0 | Common Stock | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 1,924 | 11,964 | - | 0 | Common Stock | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 2,000 | 22,000 | - | - | Restricted Stock Units | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 1,924 | 19,241 | - | - | Restricted Stock Units | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 9.65 per share. | 30 Jul 2023 | 1,420 | 12,544 | - | 9.7 | 13,710 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 2,000 | 13,964 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 2,000 | 83,816 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 2,000 | 22,000 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 2,886 | 28,861 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 9.65 per share. | 30 Jul 2023 | 1,245 | 82,571 | - | 9.7 | 12,020 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2023 | 2,886 | 81,816 | - | 0 | Common Stock | |
| Julia P. Gregory | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| Judith A. Reinsdorf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| Paul M. Silva | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| Lori Anne Kunkel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| David L. Lacey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| Edward C. Saltzman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 25,000 | 25,000 | - | - | Director Stock Option (right to buy) | |
| Stefani A. Wolff | EVP and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2023 | 962 | 10,582 | - | - | Restricted Stock Units | |
| Stefani A. Wolff | EVP and COO | Sale of securities on an exchange or to another person at price $ 9.88 per share. | 30 Apr 2023 | 342 | 6,113 | - | 9.9 | 3,378 | Common Stock |
| Stefani A. Wolff | EVP and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2023 | 962 | 6,455 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2023 | 3,206 | 27,768 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 9.88 per share. | 30 Apr 2023 | 1,136 | 26,632 | - | 9.9 | 11,219 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2023 | 3,206 | 35,275 | - | - | Restricted Stock Units | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2023 | 1,924 | 10,722 | - | 0 | Common Stock | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 9.88 per share. | 30 Apr 2023 | 682 | 10,040 | - | 9.9 | 6,736 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2023 | 1,924 | 21,165 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2023 | 2,886 | 31,747 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 9.88 per share. | 30 Apr 2023 | 721 | 78,930 | - | 9.9 | 7,121 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2023 | 2,886 | 79,651 | - | 0 | Common Stock | |
| Arthur T. Sands | Director, President, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2023 | 448,000 | 448,000 | - | - | Employee Stock Option (right to buy) | |
| Stefani A. Wolff | EVP and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2023 | 24,000 | 24,000 | - | - | Restricted Stock Units | |
| Stefani A. Wolff | EVP and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2023 | 88,900 | 88,900 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2023 | 24,000 | 24,000 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2023 | 88,900 | 88,900 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2023 | 24,000 | 24,000 | - | - | Restricted Stock Units | |
| Christine Ring | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2023 | 88,900 | 88,900 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2023 | 24,000 | 24,000 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Feb 2023 | 88,900 | 88,900 | - | - | Employee Stock Option (right to buy) | |
| Stefani A. Wolff | EVP and COO | Sale of securities on an exchange or to another person at price $ 11.78 per share. | 30 Jan 2023 | 424 | 3,940 | - | 11.8 | 4,995 | Common Stock |
| Stefani A. Wolff | EVP and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2023 | 962 | 11,544 | - | - | Restricted Stock Units | |
| Stefani A. Wolff | EVP and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2023 | 962 | 4,364 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2023 | 3,207 | 24,421 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2023 | 3,207 | 38,481 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 11.78 per share. | 30 Jan 2023 | 1,412 | 23,009 | - | 11.8 | 16,633 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 11.78 per share. | 30 Jan 2023 | 848 | 7,261 | - | 11.8 | 9,989 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2023 | 1,924 | 23,089 | - | - | Restricted Stock Units | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2023 | 1,924 | 8,109 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2023 | 2,886 | 77,689 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jan 2023 | 2,886 | 34,633 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 11.78 per share. | 30 Jan 2023 | 924 | 76,765 | - | 11.8 | 10,884 | Common Stock |
| Stefani A. Wolff | EVP and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2022 | 962 | 12,506 | - | - | Restricted Stock Units | |
| Stefani A. Wolff | EVP and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2022 | 962 | 3,752 | - | 0 | Common Stock | |
| Stefani A. Wolff | EVP and COO | Sale of securities on an exchange or to another person at price $ 12.88 per share. | 30 Oct 2022 | 350 | 3,402 | - | 12.9 | 4,508 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 12.88 per share. | 30 Oct 2022 | 1,165 | 21,214 | - | 12.9 | 15,006 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2022 | 3,207 | 41,688 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2022 | 3,207 | 22,379 | - | 0 | Common Stock | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2022 | 1,924 | 25,013 | - | - | Restricted Stock Units | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 12.88 per share. | 30 Oct 2022 | 699 | 6,185 | - | 12.9 | 9,003 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2022 | 1,924 | 6,884 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2022 | 2,886 | 37,519 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2022 | 2,886 | 75,542 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 12.88 per share. | 30 Oct 2022 | 739 | 74,803 | - | 12.9 | 9,519 | Common Stock |
| Edward C. Saltzman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Sep 2022 | 50,000 | 50,000 | - | - | Director Stock Option (right to buy) | |
| Arthur T. Sands | Director, President, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Aug 2022 | 400,000 | 400,000 | - | - | Employee Stock Option (right to buy) | |
| Stefani A. Wolff | EVP and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Aug 2022 | 110,375 | 110,375 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Aug 2022 | 60,298 | 60,298 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Aug 2022 | 40,199 | 40,199 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 Aug 2022 | 120,000 | 120,000 | - | - | Employee Stock Option (right to buy) | |
| Stefani A. Wolff | EVP and COO | Sale of securities on an exchange or to another person at price $ 15.67 per share. | 30 Jul 2022 | 356 | 1,238 | - | 15.7 | 5,579 | Common Stock |
| Stefani A. Wolff | EVP and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2022 | 962 | 13,468 | - | - | Restricted Stock Units | |
| Stefani A. Wolff | EVP and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2022 | 962 | 1,594 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2022 | 3,207 | 44,895 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 15.67 per share. | 30 Jul 2022 | 1,186 | 19,172 | - | 15.7 | 18,585 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2022 | 3,207 | 20,358 | - | 0 | Common Stock | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2022 | 1,924 | 5,327 | - | 0 | Common Stock | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2022 | 1,924 | 26,937 | - | - | Restricted Stock Units | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 15.67 per share. | 30 Jul 2022 | 712 | 4,615 | - | 15.7 | 11,157 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2022 | 2,886 | 73,408 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Jul 2022 | 2,886 | 40,405 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 15.67 per share. | 30 Jul 2022 | 752 | 72,656 | - | 15.7 | 11,784 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 May 2022 | 68,333 | 0 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.84 per share. | 31 May 2022 | 68,333 | 70,522 | - | 0.8 | 57,400 | Common Stock |
| Julia P. Gregory | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2022 | 17,500 | 17,500 | - | - | Director Stock Option (right to buy) | |
| Clay B. Siegall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2022 | 17,500 | 17,500 | - | - | Director Stock Option (right to buy) | |
| Judith A. Reinsdorf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2022 | 17,500 | 17,500 | - | - | Director Stock Option (right to buy) | |
| Paul M. Silva | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2022 | 17,500 | 17,500 | - | - | Director Stock Option (right to buy) | |
| Lori Anne Kunkel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2022 | 17,500 | 17,500 | - | - | Director Stock Option (right to buy) | |
| David L. Lacey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 May 2022 | 17,500 | 17,500 | - | - | Director Stock Option (right to buy) | |
| Stefani A. Wolff | EVP and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2022 | 962 | 962 | - | 0 | Common Stock | |
| Stefani A. Wolff | EVP and COO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2022 | 962 | 14,430 | - | - | Restricted Stock Units | |
| Stefani A. Wolff | EVP and COO | Sale of securities on an exchange or to another person at price $ 11.75 per share. | 30 Apr 2022 | 330 | 632 | - | 11.8 | 3,878 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2022 | 3,206 | 18,249 | - | 0 | Common Stock | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2022 | 3,206 | 48,102 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 11.75 per share. | 30 Apr 2022 | 1,098 | 17,151 | - | 11.8 | 12,902 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 11.75 per share. | 30 Apr 2022 | 660 | 3,403 | - | 11.8 | 7,755 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2022 | 1,924 | 28,861 | - | - | Restricted Stock Units | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2022 | 1,924 | 4,063 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2022 | 2,886 | 2,886 | - | 0 | Common Stock | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Apr 2022 | 2,886 | 43,291 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 11.75 per share. | 30 Apr 2022 | 697 | 2,189 | - | 11.8 | 8,190 | Common Stock |
| Arthur T. Sands | Director, President, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Jan 2022 | 300,000 | 300,000 | - | - | Employee Stock Option (right to buy) | |
| Stefani A. Wolff | EVP and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2022 | 34,631 | 34,631 | - | - | Employee Stock Option (right to buy) | |
| Stefani A. Wolff | EVP and COO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2022 | 15,392 | 15,392 | - | - | Restricted Stock Units | |
| Gwenn Hansen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2022 | 115,438 | 115,438 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2022 | 51,308 | 51,308 | - | - | Restricted Stock Units | |
| Christine Ring | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2022 | 30,785 | 30,785 | - | - | Restricted Stock Units | |
| Christine Ring | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2022 | 69,262 | 69,262 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2022 | 46,177 | 46,177 | - | - | Restricted Stock Units | |
| Hans van Houte | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jan 2022 | 103,894 | 103,894 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 27.14 per share. | 10 Jan 2022 | 1,200 | 1,286 | - | 27.1 | 32,568 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jan 2022 | 1,200 | 100,066 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 10 Jan 2022 | 1,200 | 2,486 | - | 1.9 | 2,232 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.57 per share. | 03 Jan 2022 | 1,428 | 16,025 | - | 9.6 | 13,666 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2022 | 1,428 | 81,905 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jan 2022 | 400 | 67,466 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 28.96 per share. | 03 Jan 2022 | 1,828 | 14,197 | - | 29.0 | 52,939 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 03 Jan 2022 | 400 | 14,597 | - | 7.3 | 2,904 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Dec 2021 | 1,200 | 101,266 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 29.04 per share. | 10 Dec 2021 | 1,200 | 1,286 | - | 29.0 | 34,848 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 10 Dec 2021 | 1,200 | 2,486 | - | 1.9 | 2,232 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 01 Dec 2021 | 400 | 14,597 | - | 7.3 | 2,904 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Dec 2021 | 400 | 67,866 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 29.13 per share. | 01 Dec 2021 | 400 | 14,197 | - | 29.1 | 11,652 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 32.38 per share. | 10 Nov 2021 | 1,200 | 1,286 | - | 32.4 | 38,856 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Nov 2021 | 1,200 | 102,466 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 10 Nov 2021 | 1,200 | 2,486 | - | 1.9 | 2,232 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 33.24 per share. | 01 Nov 2021 | 400 | 14,197 | - | 33.2 | 13,296 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Nov 2021 | 400 | 68,266 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 01 Nov 2021 | 400 | 14,597 | - | 7.3 | 2,904 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 27 Oct 2021 | 400 | 14,197 | - | 35 | 14,000 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Oct 2021 | 400 | 68,666 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 27 Oct 2021 | 400 | 14,597 | - | 7.3 | 2,904 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 35.25 per share. | 27 Oct 2021 | 800 | 1,286 | - | 35.3 | 28,200 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Oct 2021 | 800 | 103,666 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 27 Oct 2021 | 800 | 2,086 | - | 1.9 | 1,488 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 11 Oct 2021 | 1,200 | 2,486 | - | 1.9 | 2,232 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Oct 2021 | 1,200 | 104,466 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 27.36 per share. | 11 Oct 2021 | 1,200 | 1,286 | - | 27.4 | 32,832 | Common Stock |
| Judith A. Reinsdorf | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2021 | 35,000 | 35,000 | - | - | Director Stock Option (right to buy) | |
| Paul M. Silva | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2021 | 35,000 | 35,000 | - | - | Director Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Oct 2021 | 400 | 69,066 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 29.92 per share. | 01 Oct 2021 | 400 | 14,197 | - | 29.9 | 11,968 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 01 Oct 2021 | 400 | 14,597 | - | 7.3 | 2,904 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 35.10 per share. | 10 Sep 2021 | 700 | 2,586 | - | 35.1 | 24,568 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Sep 2021 | 2,000 | 105,666 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 36.76 per share. | 10 Sep 2021 | 800 | 1,286 | - | 36.8 | 29,408 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 35.77 per share. | 10 Sep 2021 | 500 | 2,086 | - | 35.8 | 17,884 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 10 Sep 2021 | 2,000 | 3,286 | - | 1.9 | 3,720 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 07 Sep 2021 | 1,600 | 14,197 | - | 35 | 56,000 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Sep 2021 | 1,600 | 69,466 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 07 Sep 2021 | 1,600 | 15,797 | - | 7.3 | 11,616 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 07 Sep 2021 | 3,200 | 4,486 | - | 1.9 | 5,952 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Sep 2021 | 3,200 | 107,666 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 35.25 per share. | 07 Sep 2021 | 3,200 | 1,286 | - | 35.3 | 112,800 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 32.34 per share. | 01 Sep 2021 | 400 | 14,197 | - | 32.3 | 12,936 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Sep 2021 | 400 | 71,066 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 01 Sep 2021 | 400 | 14,597 | - | 7.3 | 2,904 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.11 per share. | 10 Aug 2021 | 7,500 | 11,830 | - | 1.1 | 8,325 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Aug 2021 | 7,500 | 6,562 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 30.21 per share. | 10 Aug 2021 | 1,880 | 4,330 | - | 30.2 | 56,797 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 29.74 per share. | 10 Aug 2021 | 5,620 | 6,210 | - | 29.7 | 167,129 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 29.87 per share. | 10 Aug 2021 | 1,200 | 805 | - | 29.9 | 35,845 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Aug 2021 | 1,200 | 110,866 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 10 Aug 2021 | 1,200 | 2,005 | - | 1.9 | 2,232 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 31.21 per share. | 02 Aug 2021 | 400 | 13,804 | - | 31.2 | 12,484 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 02 Aug 2021 | 400 | 71,466 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 02 Aug 2021 | 400 | 14,204 | - | 7.3 | 2,904 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 27.00 per share. | 20 Jul 2021 | 1,200 | 805 | - | 27 | 32,400 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2021 | 1,200 | 112,066 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 20 Jul 2021 | 1,200 | 2,005 | - | 1.9 | 2,232 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 23.88 per share. | 12 Jul 2021 | 7,100 | 4,730 | - | 23.9 | 169,527 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jul 2021 | 7,500 | 14,062 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 24.73 per share. | 12 Jul 2021 | 400 | 4,330 | - | 24.7 | 9,892 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.11 per share. | 12 Jul 2021 | 7,500 | 11,830 | - | 1.1 | 8,325 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 26.76 per share. | 01 Jul 2021 | 400 | 13,804 | - | 26.8 | 10,704 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2021 | 400 | 71,866 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 01 Jul 2021 | 400 | 14,204 | - | 7.3 | 2,904 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 29.15 per share. | 10 Jun 2021 | 6,000 | 5,830 | - | 29.1 | 174,881 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 30.90 per share. | 10 Jun 2021 | 400 | 4,330 | - | 30.9 | 12,361 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 30.01 per share. | 10 Jun 2021 | 1,100 | 4,730 | - | 30.0 | 33,006 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.11 per share. | 10 Jun 2021 | 7,500 | 11,830 | - | 1.1 | 8,325 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2021 | 7,500 | 21,562 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Jun 2021 | 1,200 | 113,266 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 30.52 per share. | 10 Jun 2021 | 200 | 805 | - | 30.5 | 6,103 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 29.18 per share. | 10 Jun 2021 | 1,000 | 1,005 | - | 29.2 | 29,179 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 10 Jun 2021 | 1,200 | 2,005 | - | 1.9 | 2,232 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 01 Jun 2021 | 400 | 14,204 | - | 7.3 | 2,904 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2021 | 400 | 72,266 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 27.74 per share. | 01 Jun 2021 | 400 | 13,804 | - | 27.7 | 11,096 | Common Stock |
| Clay B. Siegall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 May 2021 | 35,000 | 35,000 | - | - | Director Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.11 per share. | 10 May 2021 | 7,500 | 11,830 | - | 1.1 | 8,325 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2021 | 7,500 | 29,062 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 27.66 per share. | 10 May 2021 | 700 | 4,330 | - | 27.7 | 19,363 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 26.87 per share. | 10 May 2021 | 2,501 | 5,030 | - | 26.9 | 67,213 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 26.07 per share. | 10 May 2021 | 4,299 | 7,531 | - | 26.1 | 112,068 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 27.00 per share. | 10 May 2021 | 1,200 | 805 | - | 27 | 32,400 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 10 May 2021 | 1,200 | 2,005 | - | 1.9 | 2,232 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2021 | 1,200 | 114,466 | - | - | Employee Stock Option (right to buy) | |
| Julia P. Gregory | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2021 | 17,500 | 17,500 | - | - | Director Stock Option (right to buy) | |
| Lori Anne Kunkel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2021 | 17,500 | 17,500 | - | - | Director Stock Option (right to buy) | |
| David L. Lacey | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2021 | 17,500 | 17,500 | - | - | Director Stock Option (right to buy) | |
| Leon Chen | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2021 | 17,500 | 17,500 | - | - | Director Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 May 2021 | 800 | 72,666 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 03 May 2021 | 800 | 14,604 | - | 7.3 | 5,808 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 03 May 2021 | 800 | 13,804 | - | 35.0 | 27,996 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 28 Apr 2021 | 800 | 1,605 | - | 1.9 | 1,488 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 35.25 per share. | 28 Apr 2021 | 800 | 805 | - | 35.3 | 28,200 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Apr 2021 | 800 | 115,666 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.11 per share. | 12 Apr 2021 | 5,104 | 11,830 | - | 1.1 | 5,665 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2021 | 5,104 | 36,562 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 27.67 per share. | 12 Apr 2021 | 2,883 | 4,875 | - | 27.7 | 79,770 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 26.83 per share. | 12 Apr 2021 | 4,072 | 7,758 | - | 26.8 | 109,245 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.84 per share. | 12 Apr 2021 | 2,396 | 6,726 | - | 0.8 | 2,013 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2021 | 2,396 | 0 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 28.66 per share. | 12 Apr 2021 | 545 | 4,330 | - | 28.7 | 15,617 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 12 Apr 2021 | 1,200 | 2,005 | - | 1.9 | 2,232 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 27.20 per share. | 12 Apr 2021 | 1,200 | 805 | - | 27.2 | 32,640 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2021 | 1,200 | 116,466 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Apr 2021 | 400 | 73,466 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.00 per share. | 05 Apr 2021 | 400 | 13,804 | - | 35 | 14,000 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 05 Apr 2021 | 400 | 14,204 | - | 7.3 | 2,904 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2021 | 400 | 73,866 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 31.55 per share. | 01 Apr 2021 | 400 | 13,804 | - | 31.6 | 12,620 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 01 Apr 2021 | 400 | 14,204 | - | 7.3 | 2,904 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.84 per share. | 25 Mar 2021 | 4,330 | 4,330 | - | 0.8 | 3,637 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2021 | 4,330 | 2,396 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 16 Mar 2021 | 800 | 13,804 | - | 45 | 36,000 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2021 | 800 | 74,266 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 16 Mar 2021 | 800 | 14,604 | - | 7.3 | 5,808 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 39.44 per share. | 10 Mar 2021 | 900 | 1,905 | - | 39.4 | 35,496 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Mar 2021 | 2,000 | 117,666 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 44.11 per share. | 10 Mar 2021 | 395 | 805 | - | 44.1 | 17,425 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 42.67 per share. | 10 Mar 2021 | 405 | 1,200 | - | 42.7 | 17,280 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 41.13 per share. | 10 Mar 2021 | 300 | 1,605 | - | 41.1 | 12,339 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 10 Mar 2021 | 2,000 | 2,805 | - | 1.9 | 3,720 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 37.31 per share. | 08 Mar 2021 | 4,490 | 200 | - | 37.3 | 167,504 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Mar 2021 | 7,500 | 6,726 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 38.34 per share. | 08 Mar 2021 | 200 | 0 | - | 38.3 | 7,668 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.84 per share. | 08 Mar 2021 | 7,500 | 7,500 | - | 0.8 | 6,300 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 36.48 per share. | 08 Mar 2021 | 2,810 | 4,690 | - | 36.5 | 102,507 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Mar 2021 | 800 | 75,066 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.95 per share. | 01 Mar 2021 | 800 | 13,804 | - | 36.0 | 28,760 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 01 Mar 2021 | 800 | 14,604 | - | 7.3 | 5,808 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.20 per share. | 24 Feb 2021 | 20,393 | 20,393 | - | 1.2 | 24,472 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2021 | 1,829 | 36,504 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2021 | 13,197 | 20,136 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Feb 2021 | 20,393 | 9,027 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 39.90 per share. | 24 Feb 2021 | 35,419 | 0 | - | 39.9 | 1,413,218 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 24 Feb 2021 | 1,829 | 35,419 | - | 7.3 | 13,279 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 24 Feb 2021 | 13,197 | 33,590 | - | 1.9 | 24,546 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.20 per share. | 22 Feb 2021 | 3,913 | 5,330 | - | 1.2 | 4,696 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2021 | 3,913 | 29,420 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Feb 2021 | 1,417 | 68,333 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 39.93 per share. | 22 Feb 2021 | 5,330 | 0 | - | 39.9 | 212,839 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.84 per share. | 22 Feb 2021 | 1,417 | 1,417 | - | 0.8 | 1,190 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 36.92 per share. | 18 Feb 2021 | 1,000 | 400 | - | 36.9 | 36,924 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2021 | 2,096 | 14,678 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2021 | 3,797 | 72,869 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2021 | 9,107 | 14,226 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 37.88 per share. | 18 Feb 2021 | 400 | 0 | - | 37.9 | 15,150 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 35.99 per share. | 18 Feb 2021 | 6,400 | 1,400 | - | 36.0 | 230,328 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 35.02 per share. | 18 Feb 2021 | 4,553 | 7,800 | - | 35.0 | 159,454 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 34.19 per share. | 18 Feb 2021 | 2,647 | 12,353 | - | 34.2 | 90,496 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 9.57 per share. | 18 Feb 2021 | 2,096 | 15,000 | - | 9.6 | 20,059 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 18 Feb 2021 | 3,797 | 12,904 | - | 7.3 | 27,566 | Common Stock |
| Pierre Beaurang | Chief Business Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.84 per share. | 18 Feb 2021 | 9,107 | 9,107 | - | 0.8 | 7,650 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 35.81 per share. | 18 Feb 2021 | 600 | 12,200 | - | 35.8 | 21,484 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 7.26 per share. | 18 Feb 2021 | 800 | 12,800 | - | 7.3 | 5,808 | Common Stock |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2021 | 800 | 75,866 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 37.67 per share. | 18 Feb 2021 | 200 | 12,000 | - | 37.7 | 7,534 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 34.48 per share. | 18 Feb 2021 | 400 | 1,600 | - | 34.5 | 13,790 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.86 per share. | 18 Feb 2021 | 2,000 | 2,000 | - | 1.9 | 3,720 | Common Stock |
| Christine Ring | General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2021 | 2,000 | 119,666 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 37.03 per share. | 18 Feb 2021 | 500 | 0 | - | 37.0 | 18,516 | Common Stock |
| Christine Ring | General Counsel | Sale of securities on an exchange or to another person at price $ 35.86 per share. | 18 Feb 2021 | 1,100 | 500 | - | 35.9 | 39,444 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 34.24 per share. | 18 Feb 2021 | 3,140 | 10,443 | - | 34.2 | 107,511 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.84 per share. | 18 Feb 2021 | 13,583 | 13,583 | - | 0.8 | 11,410 | Common Stock |
| Hans van Houte | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Feb 2021 | 13,583 | 69,750 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 38.05 per share. | 18 Feb 2021 | 400 | 0 | - | 38.0 | 15,219 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 36.91 per share. | 18 Feb 2021 | 666 | 400 | - | 36.9 | 24,581 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 36.00 per share. | 18 Feb 2021 | 5,725 | 1,066 | - | 36.0 | 206,109 | Common Stock |
| Hans van Houte | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 35.10 per share. | 18 Feb 2021 | 3,652 | 6,791 | - | 35.1 | 128,201 | Common Stock |
| Arthur T. Sands | Director, President, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2021 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Pierre Beaurang | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2021 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2021 | 60,000 | 60,000 | - | - | Employee Stock Option (right to buy) | |
| Christine Ring | General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2021 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Hans van Houte | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Feb 2021 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Nov 2020 | 12,000 | 31,333 | - | - | Employee Stock Option (right to buy) | |
| Gwenn Hansen | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.84 per share. | 30 Nov 2020 | 12,000 | 12,000 | - | 0.8 | 10,080 | Common Stock |
| Arthur T. Sands | Director, President, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Oct 2020 | 804,170 | 804,170 | - | - | Stock Option (right to buy) | |
| Robert Tjian | Director | 28 Jul 2020 | 50,000 | 0 | - | - | Series B Preferred Stock | ||
| Robert Tjian | Director | 28 Jul 2020 | 41,666 | 0 | - | - | Series A-2 Preferred Stock | ||
| Robert Tjian | Director | 28 Jul 2020 | 50,000 | 124,999 | - | - | Common Stock | ||
| Robert Tjian | Director | 28 Jul 2020 | 41,666 | 74,999 | - | - | Common Stock |